Find Answers You're Looking for with SocialScour.com Chromogranin A: its role in endocrine function and as an endocrine marker and neuroendocrine tumor. Deftos LJ. Endocr Rev 1991 May;12(2):181-7 CgA is of diagnostic value in classical endocrine tumors, in hormone-negative tumors, and in endocrine tumors in which other diagnostic procedures have their limitations. . . I assume you are most concerned about carcinoid syndrome based on the elevation of chromogranin A. Therefore, I think it is important to understand the role of chromogranin A in the diagnosis of carcinoid tumors. First, and most importantly, is that chromogranin A is not a specific marker for carcinoid tumors
Chromogranin A serum or plasma levels reflect tumor load, and it may be an independent marker of prognosis in patients with midgut carcinoids. The measurement of CgA is considered the gold standard of chemical tests for confirming the diagnosis of carcinoid and neuroendocrine tumors and following their course Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins, i.e., it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in pancreas The Biological Purpose Of Chromogranin A. For our purposes of understanding carcinoid and net cancer, Chromogranin A is a protein that is secreted by our neuroendocrine cells. My understanding is that it is used to signal the cell to perform a certain function. There are 2 types of functions caused by the chromogranisn on cells 3.2 Chromogranin related to net The Chromogranin A test is used often as a tumor marker. It may be ordered in combination with or in place of 5-HIAA to help diagnose carcinoid tumors. It is also used to help monitor the effectiveness of treatment and detect recurrence of this tumor. Sometimes it may b
CGAK : Chromogranin A (CGA) is a 439-amino acid protein with a molecular weight of 48 to 60 kDa, depending on glycosylation and phosphorylation status. It is a member of the granin family of proteins and polypeptides I was diagnosed with carcinoid syndrome 4 years ago and a large tumor in my cecum was removed but it had already metastisized to my liver where they were watching their growth etc so I have chromogranin A every other month and 5-HIAA so I may be able to clear up some of the questions As a result of the carcinoid syndrome: Chronic flushing and/or diarrhea are the typical manifestations of the carcinoid syndrome, which is the result of secretion of serotonin and other vasoactive substances into the systemic circulation. The carcinoid syndrome is primarily associated with metastatic tumors originating in the midgut (distal.
Carcinoid syndrome is a paraneoplastic syndrome comprising the signs and symptoms that occur secondary to carcinoid tumors. The syndrome includes flushing and diarrhea, and less frequently, heart failure, emesis and bronchoconstriction. It is caused by endogenous secretion of mainly serotonin and kallikrein Chromogranin A is a member of the granin family of proteins that are present within the secretory granules of cells in endocrine, neuroendocrine, and nerve tissues. Chromogranin A is a useful diagnostic biomarker for neuroendocrine tumors such as carcinoid tumors, pheochromocytoma and neuroblastoma The chromogranin A test is used to detect tumors including carcinoid tumors, insulinomas, small cell lung cancers, and neuroblastomas. According to the study, CgA is a useful tool in the monitoring of enterochromaffin-like (ECL) hyperplasia secondary to treatment with acid secretion inhibitors or atrophic gastritis
CGAK : Follow-up or surveillance of patients with known or treated carcinoid tumors An adjunct in the diagnosis of carcinoid tumors An adjunct in the diagnosis of other neuroendocrine tumors, including pheochromocytomas, medullary thyroid carcinomas, functioning and nonfunctioning islet cell and gastrointestinal amine precursor uptake and decarboxylation tumors, and pituitary adenomas A. Chromogranin A (CgA) is used as an adjunct in the diagnosis of carcinoid tumors. Measurements of CgA are also used to assess disease progression, response to therapy, or recurrence after surgical resection The chromogranin A (CgA) test is used as a tumour marker.It may be ordered in combination with a 5-HIAA test to help diagnose carcinoid tumours.It may also be used to detect the presence of other tumours arising from neuroendocrine cells
If you look at the archives of the Carcinoid Listserve available there, you will find lots of discussion about it. I believe Dr. Woltering also has a published paper that indicates there may be a better marker than Chromogranin A. I know it is affected by use of protein pump inhibitors such as Prilosec, as well as a few other things chromogranin A - MedHelp's chromogranin A Center for Information, Symptoms, Resources, Treatments and Tools for chromogranin A. Find chromogranin A information, treatments for chromogranin A and chromogranin A symptoms Learn about the causes, symptoms, diagnosis, and treatment of carcinoid tumors, a type of cancer that can show up in many different places in your body Carcinoid syndrome is a group of symptoms you might get if you already have a type of cancer called carcinoid tumors. It starts when the tumors release chemicals into your bloodstream. The.
Carcinoid syndrome. Carcinoid syndrome causes redness or a feeling of warmth in your face and neck (skin flushing), chronic diarrhea, and difficulty breathing, among other signs and symptoms. Carcinoid heart disease. Carcinoid tumors may secrete hormones that can cause thickening of the lining of heart chambers, valves and blood vessels Metastatic carcinoid tumors most commonly come from neuroendocrine cells found in the gastrointestinal (GI) tract, which includes the stomach and the small and large intestines (see figure). Carcinoid syndrome refers to the group of symptoms that result from active carcinoid tumors